|
KMID : 1144320160480040330
|
|
감염과 화학요법
2016 Volume.48 No. 4 p.330 ~ p.333
|
|
|
Epstein-Barr Virus Associated Hemophagocytic Syndrome after Scrub Typhus Infection
|
|
Hong Jeong-Woo
You Hyun-Seon
Lee Tae-Won
Jo Won-Yong
Kim Bo-Ra
Suh Young-Sun
Bae In-Gyu
Cho Oh-Hyun
|
|
|
Abstract
|
|
|
|
There have been a small number of cases of scrub typhus-associated hemophagocytic syndrome (HPS), most of which were treated successfully using adequate antibiotics. Here, we report a case of Epstein-Barr virus (EBV)-associated HPS after scrub typhus infection that was not improved using antirickettsial treatment. A 73-year-old male who had been diagnosed with scrub typhus according to an eschar and a positive serology was transferred to our institution because of a persistent fever despite 7-day doxycycline therapy. Physical and laboratory data showed hepatosplenomegaly, bicytopenia, hyperferritinemia, and hypofibrinogenemia. A bone marrow examination (BM) revealed hypercellular marrow with hemophagocytosis and histiocyte infiltration. EBV was detected in BM aspirates using polymerase chain reaction. After a diagnosis of HPS was made, the patient was treated successfully using high-dose steroids.
|
|
|
KEYWORD
|
|
|
Epstein-Barr virus infections, Lymphohistiocytosis, Hemophagocytic, Scrub typhus
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|